Piperidino-dihydrothienopyrimidine sulfoxides and their use for treating COPD and asthma

US9150586B2 · kind B2 · utility

Assignee

• Boehringer Ingelheim International GmbH · DE

Inventors

• Pascale Pouzet · Biberach, DE
• Peter Nickolaus · Warthausen, DE
• Ulrike Werthmann · Biberach an der Riß, DE
• Rogelio P. Frutos · Sandy Hook, US
• Bing-Shiou Yang · Southbury, US
• Soojin Kim · West Orange, US
• Jason Alan Mulder · New Milford, US
• Nitinchandra D. Patel · Danbury, US
• Chris Hugh Senanayake · Brookfield, US
• Thomas G. Tampone · Southbury, US
• Xudong Wei · West Greenwich, US

Key dates

• Filing date: Mar 15, 2012
• Grant date: Oct 6, 2015
• Expiry date: Mar 15, 2032

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C07B2200/13
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

The invention relates to novel piperidino-dihydrothienopyrimidine sulfoxides of formula I,wherein Ring A is a 6-membered aromatic ring which may optionally comprise one or two nitrogen atoms andwherein R is Cl andwherein R may be located either in the para-, meta- or ortho-position of Ring A,wherein S* is a sulphur atom that represents a chiral center,and all pharmaceutically acceptable salts, enantiomers and racemates, hydrates and solvates thereof and the use of these compounds for the treatment of inflammatory or allergic diseases of the respiratory tract such as COPD or asthma.