Polyethylene glycolated superoxide dismutase mimetics
US9150837B2 · kind B2 · utility
Assignee
Inventors
Key dates
| Filing date | Jun 27, 2013 |
| Grant date | Oct 6, 2015 |
| Priority date | — |
| Expiry date | Jun 27, 2033 |
Classification
- Technology area (CPC G)Physics
- CPC primaryG01N33/5014
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
Compounds and methods for utilizing compounds comprising a superoxide dismutase mimetic covalently linked to polyethylene glycol. Methods are also provided for preparing a superoxide dismutase mimetic covalently linked to a polyethylene glycol, the methods comprising reacting an activated polyethylene glycol with a superoxide dismutase mimetic, or alternatively, reacting a superoxide dismutase mimetic with an activated polyethylene glycol. A method is also provided for preventing or treating a disease or disorder in which superoxide anions are implicated, comprising administering to a subject in need thereof, a therapeutically effective amount of a compound comprising a superoxide dismutase mimetic covalently linked to a polyethylene glycol. Methods of determining the safety and efficacy of the compounds are also provided. Methods for determining the safety and efficacy can include methods in lab animals and humans.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.