Heterologous expression of Neisserial proteins

US9150898B2 · kind B2 · utility

Assignee

• GLAXOSMITHKLINE BIOLOGICALS SA · BE

Inventors

• Maria Arico · Quercegrossa, IT
• Maurizio Comanducci · Siena, IT
• Cesira Galeotti · Poggibonsi, IT
• Vega Masignani · Siena, IT
• Marzia Monica Giuliani · Siena, IT
• Mariagrazia Pizza · Siena, IT

Key dates

• Filing date: Jul 31, 2014
• Grant date: Oct 6, 2015
• Expiry date: Jul 31, 2034

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C12Q2600/156
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

Alternative and improved approaches to the heterologous expression of the proteins of Neisseria meningitidis and Neisseria gonorrhoeae are disclosed. These approaches typically affect the level of expression, the ease of purification, the cellular localization, and/or the immunological properties of the expressed protein.