Benzoimidazole-carboxylic acid amide derivatives as APJ receptor modulators

US9156796B2 · kind B2 · utility

Assignee

• Sanofi · FR

Inventors

• Stephanie Hachtel · Frankfurt am Main, DE
• Paulus Wohlfart · Frankfurt am Main, DE
• John Weston · Frankfurt am Main, DE
• Marco Mueller · Frankfurt am Main, DE
• Elisabeth Defossa · Idstein, DE
• Katharina Mertsch · Frankfurt am Main, DE
• Jian-Hui Weng · Oro Valley, US
• Robert A. Binnie · Tucson, US
• Farid Abdul-Latif · Oro Valley, US
• William Jerome Bock · Tucson, US
• Armin Walser · Tucson, US

Key dates

• Filing date: Sep 19, 2013
• Grant date: Oct 13, 2015
• Expiry date: Sep 19, 2033

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C07D487/08
• WIPO field: Organic fine chemistry
• WIPO sector: Chemistry

Abstract

The present invention relates to benzoimidazole-carboxylic acid amide compounds of the formula I,in which R′, R″, R′″, R1, R2, R3, R4, R5, R6 and Z are defined as indicated below. The compounds of the formula I are APJ receptor modulators, and are useful for the treatment of diseases associated with increased blood pressure for example. The invention furthermore relates to the use of compounds of the formula I, in particular as active ingredients in pharmaceuticals, and pharmaceutical compositions comprising them.