Double-liver-targeting phosphoramidate and phosphonoamidate prodrugs
US9156874B2 · kind B2 · utility
17Cited by
0References
20Claims
0Family size
Assignee
Inventors
Key dates
| Filing date | Mar 15, 2013 |
| Grant date | Oct 13, 2015 |
| Priority date | — |
| Expiry date | Sep 11, 2033 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC07F9/26
- WIPO fieldOrganic fine chemistry
- WIPO sectorChemistry
Abstract
This application discloses phosphoramidate and phosphonoamidate prodrugs of alcohol-based therapeutic agents, such as nucleosides, nucleotides, acyclonucleosides, C-nucleosides, and C-nucleotides, and use of these prodrugs for treatment of diseases or disorders, including infectious diseases and cancers. This application also discloses a general method for enhancing bioavailability and/or liver-targeting property of alcohol drugs through converting the alcohol drugs to phosphoramidate or phosphonoamidate prodrugs, and methods of preparation of these prodrugs.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.