2-(2-hydroxybiphenyl-3-yl)-1H-benzoimidazole-5-carboxamidine derivatives as factor VIIA inhibitors

US9162986B2 · kind B2 · utility

Assignee

• Pharmacyclics LLC · US

Inventors

• Aleksandr Kolesnikov · Mill Valley, US
• Roopa Rai · San Carlos, US
• William D. Shrader · Belmont, US
• Steven M. Torkelson · Lawrence, US
• Kieron E. Wesson · Menlo Park, US
• Wendy B. Young · San Mateo, US

Key dates

• Filing date: Jun 27, 2014
• Grant date: Oct 20, 2015
• Expiry date: Jun 27, 2034

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C12Q1/56
• WIPO field: Organic fine chemistry
• WIPO sector: Chemistry

Abstract

The present invention relates to novel inhibitors of Factors VIIa, IXa, Xa, XIa, in particular Factor VIIa, pharmaceutical compositions comprising these inhibitors, and methods for using these inhibitors for treating or preventing thromboembolic disorders, cancer or rheumatoid arthritis. Processes for preparing these inhibitors are also disclosed.