5-substituted indazoles as kinase inhibitors

US9163007B2 · kind B2 · utility

Assignee

• Abb Vie Inc. · US

Inventors

• Irini Akritopoulou-Zanze · Libertyville, US
• Brian D. Wakefield · Skokie, US
• Helmut Mack · Ludwigshafen, DE
• Sean Colm Turner · Ludwigshafen, DE
• Alan F. Gasiecki · Vernon Hills, US
• Vijaya J. Gracias · Lindenhurst, US
• Kathy Sarris · Mundelein, US
• Douglas M. Kalvin · Buffalo Grove, US
• Melissa J. Michmerhuizen · Gurnee, US
• Qi Shuai · DeKalb, US
• Jyoti R. Patel · Libertyville, US
• Margaretha H.M. Bakker · Seeheim-Jugenheim, DE
• Nicole Teusch · Uerdingen, DE
• Eric F. Johnson · Antioch, US
• Peter J. Kovar · Chicago, US
• Stevan W. Djuric · Libertyville, US
• Andrew J. Long · Chelmsford, US
• Anil Vasudevan · Union Grove, US
• Dawn M. George · Charlton, US
• Lu Wang · Worcester, US
• Biqin C. Li · Bedford, US
• Nigel S. Moore · Shrewsbury, US
• Adrian D. Hobson · Shrewsbury, US
• Keith W. Woods · Lincolnshire, US
• Julie M. Miyashiro · Skokie, US
• Steven L. Swann, Jr. · San Diego, US
• Thomas D. Penning · Elmhurst, US

Key dates

• Filing date: Dec 20, 2013
• Grant date: Oct 20, 2015
• Expiry date: Dec 20, 2033

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C07D513/04
• WIPO field: Organic fine chemistry
• WIPO sector: Chemistry

Abstract

The present invention relates to compounds of formula (I) or pharmaceutical acceptable salts,wherein A, R1, R2, R3 and m, are defined in the description. The present invention relates also to methods of making said compounds, and compositions containing said compounds which are useful for inhibiting kinases such as Glycogen Synthase kinase 3 (GSK-3), Rho kinase (ROCK), Janus Kinases (JAK), Cdc7, AKT, PAK4, PLK, CK2, KDR, MK2, JNK1, aurora, pim 1 and nek 2.