Pyrimidines as sodium channel blockers

US9163008B2 · kind B2 · utility

Assignee

• PURDUE PHARMA L.P. · US

Inventors

• Chiyou Ni · Montgomery, US
• Bin Shao · Shanghai, CN
• Laykea Tafesse · Robinsville, US
• Jiangcho Yao · Princeton, US
• Mark A. Youngman · Warminster, US
• Minnie Park · Princeton Junction, US

Key dates

• Filing date: Aug 31, 2012
• Grant date: Oct 20, 2015
• Expiry date: Aug 31, 2032

Classification

• Technology area (CPC A): Human Necessities
• CPC primary: A61K31/506
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

The present disclosure provides substituted pyrimidine compounds of Formula (I), and the pharmaceutically acceptable salts, prodrugs, and solvates thereof, wherein A1, X, A2, W1, W2, E, Z, and R4 are defined as set forth in the specification. The present disclosure is also directed to the use of compounds of Formula (I) to treat a disorder responsive to the blockade of sodium channels. Compounds of the present disclosure are especially useful for treating pain.