Crystalline (6R,7R)-7-{2-(5-amino-[1,2,4] thiadiazol-3-yl)-2-[(Z)-trityloxyimino]-acetylamino}-3-[(R)-1′-tert-butoxycarbonyl-2-oxo-[1,3′]bipyrrolidinyl-(3E)-ylidenemethyl]-8-oxo-5-thia-1-aza-bicyclo[4.2.0]oct-2-ene-2-carboxylic acid benzhydryl ester; its manufacture and use

US9163034B2 · kind B2 · utility

Assignee

• Basilea Pharmaceutica AG · CH

Inventors

• Marco Alpegiani · Milano, IT
• Walter Cabri · Sant Celoni, ES
• Markus Heubes · Kaarst, DE
• Davide Longoni · Pioltello, IT
• Michael Schleimer · Basel, CH

Key dates

• Filing date: Sep 15, 2014
• Grant date: Oct 20, 2015
• Expiry date: Sep 15, 2034

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C07D501/54
• WIPO field: Organic fine chemistry
• WIPO sector: Chemistry

Abstract

A solid DMSO solvate of a compound of formula (I) is described, which is a useful intermediate for preparing the broad spectrum antibiotics Ceftobiprole and Ceftobiprole Medocaril.