Method for preparing ulipristal acetate and key intermediate thereof
US9163058B2 · kind B2 · utility
Assignees
Inventors
Key dates
| Filing date | Jul 12, 2012 |
| Grant date | Oct 20, 2015 |
| Priority date | — |
| Expiry date | Jul 12, 2032 |
Classification
- Technology area (CPC Y)Emerging Cross-Sectional Technologies
- CPC primaryY02P20/55
- WIPO fieldOrganic fine chemistry
- WIPO sectorChemistry
Abstract
A method as well as new intermediates for preparing Ulipristal acetate (a compound I) and a method for preparing the new intermediates are provided. The intermediate in a constitutional formula IV is conductive to reacting with methyl lithium or methyl Grignard reagent, a protective group is easy to be removed after a reaction, side reactions are few, a mid-term treatment is simple, the reagents used are cheap, costs are low and a yield is high, if a compound in a constitutional formula V is obtained by the reaction of a compound in a constitutional formula III and the intermediate in the constitutional formula IV, the yield of a two-step reaction is 75%, a purity is above 98%.wherein R is defined in the specification.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.