Methods and compositions for the treatment of proliferative and pathogenic diseases
US9163086B2 · kind B2 · utility
0Cited by
4References
34Claims
0Family size
Assignee
Inventors
Key dates
| Filing date | Aug 18, 2010 |
| Grant date | Oct 20, 2015 |
| Priority date | — |
| Expiry date | Dec 6, 2031 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC07K2317/73
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
The invention features proteins including an antibody, or functional derivatives thereof, that bind hCD59 and have the activity of domain 4 of the Streptococcus intermedins intermedilysin (ILY) protein. In order to prevent the independent induction of CDC and ADCC, the antibodies of the invention can bind the same hCD59 epitope as ILYd4 and/or contain modifications that disrupt the interaction between the antibody and complement.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.