Fatty alcohol forming acyl reductases (FARs) and methods of use thereof

US9163221B2 · kind B2 · utility

Assignee

• Codexis, Inc. · US

Inventors

• Behnaz Behrouzian · South San Francisco, US
• Louis Clark · San Francisco, US
• Yihui Zhu · Redwood City, US
• Michael D. Clay · Menlo Park, US
• Kristian Karlshoej · Naperville, US

Key dates

• Filing date: Sep 27, 2013
• Grant date: Oct 20, 2015
• Expiry date: Nov 3, 2033

Classification

• Technology area (CPC Y): Emerging Cross-Sectional Technologies
• CPC primary: Y02P30/20
• WIPO field: Basic materials chemistry
• WIPO sector: Chemistry

Abstract

The present disclosure provides methods useful for producing fatty alcohol compositions from recombinant host cells. The disclosure further provides variant fatty acyl-CoA reductase (FAR) enzymes, polynucleotides encoding the variant FAR enzymes, and vectors and host cells comprising the same.