Nucleic acids specifically binding CGRP

US9163243B2 · kind B2 · utility

Assignee

• NOXXON Pharma AG · DE

Inventors

• Simone Schulzchen · Berlin, DE
• Werner Purschke · Berlin, DE
• Florian Jarosch · Berlin, DE
• Kai Hohlig · Berlin, DE
• Christian Maasch · Berlin, DE
• Sven Klussmann · Berlin, DE

Key dates

• Filing date: Jan 10, 2013
• Grant date: Oct 20, 2015
• Expiry date: Jan 10, 2033

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C12N2320/30
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

The present invention is related to a nucleic acid molecule capable of binding to CGRP, wherein the nucleic acid molecule comprises a central stretch of nucleotides, wherein the central stretch of nucleotides comprises a nucleotide sequence of 5′ HWn1n2YGGAn3An4UMn5n6Yn7n8n9n10n11Kn12Rn13ADn14n15 ARn16Un17Cn18n19Un20n21 3′ [SEQ ID NO: 99], wherein H, W, Y, G, A, U, M, B, K, R, D, C are ribonucleotides, and n1 is R or dG, n2 is U or dT, n3 is K or dG, n4 is C or dC, n5 is M or dC, n6 is B or dU, n7 is N or dG, n8 is Y or dT, n9 is N or dC, n10 is R or dG, n11 is V or dA, n12 is K or dT or dU, n13 is G or dG, n14 is A or dA, n15 is U or dT, n16 is R or dG, n17 is Y or dC, n18 is C or dC, n19 is B or dC, n20 is C or dC, n21 is C or dC, and dG, dT, dC, dA and dU are 2′-deoxyribonucleotides.