Spiro compounds useful as inhibitors of stearoyl-coenzyme A delta-9 desaturase
US9168248B2 · kind B2 · utility
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13Claims
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Key dates
| Filing date | Feb 16, 2010 |
| Grant date | Oct 27, 2015 |
| Priority date | — |
| Expiry date | Feb 3, 2033 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC07D491/107
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
Heteroaromatic compounds of structural formula (I) are selective inhibitors of stearoyl-coenzyme A delta-9 desaturase (SCD1) relative to other known stearoyl-coenzyme A desaturases. The compounds of the present invention are useful for the prevention and treatment of conditions related to abnormal lipid synthesis and metabolism, including cardiovascular disease, such as atherosclerosis; obesity; diabetes; neurological disease; metabolic syndrome; insulin resistance; and liver steatosis.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.