Particle manipulation system with cytometric confirmation
US9168568B2 · kind B2 · utility
Assignee
Inventors
Key dates
| Filing date | Dec 12, 2013 |
| Grant date | Oct 27, 2015 |
| Priority date | — |
| Expiry date | Apr 14, 2034 |
Classification
- Technology area (CPC G)Physics
- CPC primaryG01N2015/1438
- WIPO fieldMeasurement
- WIPO sectorInstruments
Abstract
A MEMS-based particle manipulation system which uses a particle manipulation stage and a plurality of laser interrogation regions. The laser interrogation regions may be used to assess the effectiveness or accuracy of the particle manipulation stage. In one exemplary embodiment, the particle manipulation stage is a microfabricated valve, which sorts a target particle from non-target particles in a fluid stream. The laser interrogation stages are disposed in the microfabricated fluid channels at the input and output of the valve. By reversing the flow from output to input, the same laser interrogation region may be used to perform the cytometry. The cytometry may be performed throughout the sorting process to optimize or control the sorting, or may be performed afterward to allow a multi-pass, sequential sort to be performed on the same sample.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.