Patent · US Active

Efficient process for the preparation of lapatinib and salts thereof by means of new intermediates

US9169236B2 · kind B2 · utility

7Cited by

1References

23Claims

0Family size

Assignee

F.I.S. Fabbrica Italiana Sintetici S.p.A. · IT

Inventors

Francesco Fontana · Longone al Segrino, IT
Alfredo Paio · Cernusco sul Naviglio, IT

Key dates

Filing date	Feb 18, 2015
Grant date	Oct 27, 2015
Priority date	—
Expiry date	Feb 18, 2035

Classification

Technology area (CPC C)Chemistry; Metallurgy
CPC primaryC07D405/14
WIPO fieldOrganic fine chemistry
WIPO sectorChemistry

Abstract

The present invention refers to a new efficient process for the synthesis of the active pharmaceutical ingredient Lapatinib and salts thereof. In particular, the present synthesis is carried out employing new intermediates in which the amine function is protected by a group cleavable in basic milieu that provides a higher overall yield of the synthesis process.

Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.