Biocompatible agent for dispersing nanoparticles into an aqueous medium using mussel adhesive protein-mimetic polymer
US9169355B2 · kind B2 · utility
Assignee
Inventors
Key dates
| Filing date | Dec 28, 2011 |
| Grant date | Oct 27, 2015 |
| Priority date | — |
| Expiry date | Jul 11, 2032 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC08L2205/03
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
Provided are a mussel adhesive protein-mimetic dispersion stabilizing agent to disperse nanoparticles in an aqueous medium, a colloidal solution including nanoparticles dispersed and stabilized by the dispersion stabilizing agent, and a contrast agent including the colloidal solution. More particularly, the mussel adhesive protein-mimetic dispersion stabilizer is a polyethyleneimine-graft-(poly-ethyleneglycol;polyDOPA) PEI-graft-(PEG;PDOPA). The graft polymer is formed of two parts. One is polyethyleneglycol grafted with a polyethyleneime which has an affinity to an aqueous medium, and the other is polyDOPA which has an affinity to the surface of nanoparticles. Because of those characteristics, the stabilizer shows a stable dispersion of nano particles in the aqueous medium.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.