Patent · US Expired

Perivascular mesenchymal precursor cell induced blood vessel formation

US9169466B2 · kind B2 · utility

0Cited by
26References
36Claims
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Inventors

Key dates

Filing dateMar 29, 2004
Grant dateOct 27, 2015
Priority date—
Expiry dateJan 10, 2026

Classification

  • Technology area (CPC C)Chemistry; Metallurgy
  • CPC primaryC12N2506/1392
  • WIPO fieldPharmaceuticals
  • WIPO sectorChemistry

Abstract

Mesenchymal precursors cells have been isolated from perivascular niches from a range of tissues utilizing a perivascular marker. A new mesenchymal precursor cell phenotype is described characterized by the presence of the perivascular marker 3G5, and preferably also alpha smooth muscle actin together with early developmental markers such as STRO-1 and CD146/MUC18. The perivascular mesenchymal precursor cell is shown to induce neovascularization and improvement in cardiac function. Suitable administration of preparations of the mesenchymal precursor cells are useful for treatment of cardiovascular diseases, cerebrovascular diseases and peripheral vascular diseases.

Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.