Crystalline active ingredient microparticles, method for producing the same and use thereof in drugs

US9173843B2 · kind B2 · utility

Assignee

• Jesalis Pharma GmbH · DE

Inventors

• Detlef Grawe · Kleinromstedt, DE
• Sabine Gliesing · Jena, DE
• Robert Eilers · Jena, DE

Key dates

• Filing date: Jun 30, 2009
• Grant date: Nov 3, 2015
• Expiry date: Apr 12, 2031

Classification

• Technology area (CPC H): Electricity
• CPC primary: H04R5/00
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

A method for producing highly crystalline and stable microparticles of an active substance with a very narrow size distribution. The microparticles being crystallized out of a suspension made of primary particles of the active substance, a solution of the active substance, a non-solvent for the active substance and inert formed pieces. The resulting microparticles hare are highly stable largely independent of the physiochemical properties of the active substance and can be especially suitable for fast release dosage forms of pharmaceuticals.