Method of treating keloids or hypertrophic scars using antisense compounds targeting connective tissue growth factor (CTGF)
US9173894B2 · kind B2 · utility
1Cited by
17References
27Claims
0Family size
Assignee
Inventors
Key dates
| Filing date | Feb 2, 2012 |
| Grant date | Nov 3, 2015 |
| Priority date | — |
| Expiry date | Feb 5, 2033 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC12N2320/30
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
This invention provides methods of preventing formation of, or treating, fibrotic lesions, including skin scars such as keloids and hypertrophic scars which comprise administering to the subject by one or more injection a compound which comprises a modified oligonucleotide, such as a modified antisense oligonucleotide, siRNA, or oligodeoxyribonucleotide, which inhibits expression of protein involved in fibrosis. Dosing of the antisense using an intradermal threading technique is also described.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.