Dendritic high-molecular-weight polymer drug carriers and their conjugates with drugs especially for treatment of solid tumours
US9173949B2 · kind B2 · utility
Assignees
Inventors
Key dates
| Filing date | Dec 14, 2010 |
| Grant date | Nov 3, 2015 |
| Priority date | — |
| Expiry date | Jan 23, 2033 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC08G83/003
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
The present invention relates to water-soluble high-molecular-weight polymer drug carriers and their conjugates with drugs, derived from dendrimers of the amidoamine and 2,2-bis(hydroxymethyl)propanoic types, the amino and hydroxy end groups of which are attached to semitelechelic copolymers of N-(2 hydroxypropyl)methacrylamide (HPMA) through biodegradable spacers. The polymer carriers and conjugates enable targeted transport notably of anticancer drugs into solid tumors in which biodegradation, the associated controlled drug release and subsequent elimination of polymer carrier from the organism are provided. The polymer carrier conjugated with a cancerostatic for use in targeted therapy of human tumors.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.