Methods of treating cancer with low density lipoprotein-related protein 6 (LRP6)—half life extender constructs
US9173960B2 · kind B2 · utility
1Cited by
25References
30Claims
0Family size
Assignee
Inventors
Key dates
| Filing date | Aug 6, 2014 |
| Grant date | Nov 3, 2015 |
| Priority date | — |
| Expiry date | Aug 6, 2034 |
Classification
- Technology area (CPC Y)Emerging Cross-Sectional Technologies
- CPC primaryY10S424/809
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
The present invention relates to LRP6 constructs that bind to LRP6 receptor. The LRP6 constructs comprise at least one LRP6 binding moiety and a half-life extender molecule such that the LRP6 construct inhibit the Wnt signaling pathway without potentiation of the Wnt signal. The LRP6 constructs also have an increased half-life to provide more time for the therapeutic benefit.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.