Reparative cell delivery via hyaluronic acid vehicles

US9173975B2 · kind B2 · utility

Assignees

• INGENERON, INC. · US
• The Board of Regents of the University of Texas System · US

Inventors

• Andrew M Altman · Madison, US
• Eckhard Alt · Ottobrunn, DE
• Michael E. Coleman · Pompano Beach, US

Key dates

• Filing date: Apr 23, 2010
• Grant date: Nov 3, 2015
• Expiry date: Apr 23, 2030

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C12N2533/80
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

Methods are described for generating autologous tissue grafts, including generating grafts at the point of care, which include isolated cell populations that are enriched with stem cells and are mixed with hyaluronic acid and derivatives thereof. The hyaluronic acid localizes the cells to a desired injection site and stimulates collagen production thus enhancing the viability and the longevity of the graft.