Substituted 3-thiazoloamino-propionic acid derivatives and their use as pharmaceuticals

US9174952B2 · kind B2 · utility

Assignee

• Sanofi · FR

Inventors

• Sven Ruf · Mainz, DE
• Josef Pernerstorfer · Wuppertal, DE
• Thorsten Sadowski · Frankfurt am Main, DE
• Georg Horstick · Frankfurt am Main, DE
• Herman Schreuder · Frankfurt am Main, DE
• Christian Buning · Frankfurt am Main, DE
• Klaus Wirth · Frankfurt am Main, DE

Key dates

• Filing date: Jul 26, 2012
• Grant date: Nov 3, 2015
• Expiry date: Dec 15, 2033

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C07D417/04
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

The present invention relates to compounds of the formulae Ia and Ib,wherein G, R10, R30, R40, R50 and R60 have the meanings indicated in the claims, which are valuable pharmaceutical active compounds. They are inhibitors of the protease cathepsin A, and are useful for the treatment of diseases such as atherosclerosis, heart failure, renal diseases, liver diseases or inflammatory diseases, for example. The invention furthermore relates to processes for the preparation of the compounds of the formulae Ia and Ib, their use and pharmaceutical compositions comprising them.