Synthesis and use of dual tyrosyl-DNA phosphodiesterase I (Tdp1)—topoisomerase I (Top1) inhibitors
US9175002B2 · kind B2 · utility
2Cited by
6References
6Claims
0Family size
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Key dates
| Filing date | Nov 10, 2014 |
| Grant date | Nov 3, 2015 |
| Priority date | — |
| Expiry date | Nov 10, 2034 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC07D491/056
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
The invention described herein pertains to the synthesis and use of certain N-substituted indenoisoquinoline compounds which inhibit the activity Tyrosyl-DNA Phosphodiesterase I (Tdp1) or Topoisomerase I (Top1) or both, or otherwise demonstrate anticancer activity. Also disclosed are novel N-substituted indenoisoquinoline compounds and pharmaceutical compositions comprising the novel N-substituted indenoisoquinoline compounds.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.