Ketolide compounds

US9175031B2 · kind B2 · utility

Assignee

• Wockhardt Limited · IN

Inventors

• Bharat Kalidas Trivedi · Farmington Hills, US
• Prasad Keshav Deshpande · Aurangabad, IN
• Ravikumar Tadiparthi · Aurangabad, IN
• Sunil Gupta · Kota, IN
• Santosh Diwakar · Ahmednagar, IN
• Shivaji Sampatrao Pawar · Aurangabad, IN
• Vijay Patil · Solapur, IN
• Deepak Dekhane · Pune, IN
• Mahesh Vithalbhai Patel · Aurangabad, IN
• Satish Bhavsar · Aurangabad, IN
• Amit Mishra · Aurangabad, IN
• Manish Solanki · Aurangabad, IN
• Mohammad Alam Jafri · Aurangabad, IN
• Sachin Bhagwat · Aurangabad, IN

Key dates

• Filing date: Feb 3, 2011
• Grant date: Nov 3, 2015
• Expiry date: Apr 10, 2031

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C07H23/00
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

The invention relates to ketolide compounds of Formula (I) and their pharmaceutically acceptable salts, solvates, hydrates, polymorphs and stereoisomers having antimicrobial activity. The invention also provides pharmaceutical compositions containing the compounds of invention and methods of treating or preventing microbial infections with the compounds of invention, wherein, T is —C*H(R1)—P-Q; R1 is hydrogen; unsubstituted or substituted lower alkyl, cycloalkyl or aryl; P is heteroaryl ring; Q is unsubstituted or substituted aryl or heteroaryl ring; and P is attached to Q via carbon-carbon link; and R3 is hydrogen or fluorine, With the provision that when R1 is hydrogen, R3 is fluorine.