Patent · US Active

Recombinant mycobacterium avium subsp. paratuberculosis proteins induce immunity and protect against infection

US9175049B2 · kind B2 · utility

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1References

45Claims

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Assignee

The United States of America, as represented by the Secretary of Agriculture · US

Inventors

Judith R. Stabel · Ames, US
John P. Bannantine · Ames, US

Key dates

Filing date	Sep 26, 2013
Grant date	Nov 3, 2015
Priority date	—
Expiry date	Sep 26, 2033

Classification

Technology area (CPC A)Human Necessities
CPC primaryA61K2039/6068
WIPO fieldPharmaceuticals
WIPO sectorChemistry

Abstract

Compositions of immunogenic proteins of Mycobacterium avium subspecies paratuberculosis (MAP) are effective for stimulating a protective immune response in animals against MAP. Combinations of MAP1087 with two or more of MAP1204, MAP1272c and MAP2077c are effective for stimulating a protective immune response in animals against MAP and can be administered as vaccines against paratuberculosis (Johne's disease). Induction of the immune response significantly reduces or eliminates colonization of the animal by MAP, and consequently reduces or eliminates the symptoms of clinical disease in animals infected with MAP and reduces or eliminates fecal shedding of MAP. Vaccination with the compositions provides protection against clinical disease and reduces transmission of MAP infection within a herd.

Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.