Enhancement of natural killer (NK) cell proliferation and activity
US9175266B2 · kind B2 · utility
6Cited by
188References
15Claims
0Family size
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Key dates
| Filing date | Jul 19, 2013 |
| Grant date | Nov 3, 2015 |
| Priority date | — |
| Expiry date | Jul 19, 2033 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC12N2501/999
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
Methods of ex-vivo culture of natural killer (NK) cells are provided and, more particularly, methods for enhancing propagation and/or functionality of NK cells by treating the cells with an aryl hydrocarbon antagonist in combination with cytokines driving NK cell proliferation. Also envisioned are compositions comprising cultured NK cells and therapeutic uses thereof.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.