Patent · US Active

Perivascular mesenchymal precursor cell induced blood vessel formation

US9175267B2 · kind B2 · utility

2Cited by
26References
35Claims
0Family size

Assignee

Inventors

Key dates

Filing dateJan 5, 2006
Grant dateNov 3, 2015
Priority date—
Expiry dateJun 13, 2027

Classification

  • Technology area (CPC C)Chemistry; Metallurgy
  • CPC primaryC12N2506/1392
  • WIPO fieldPharmaceuticals
  • WIPO sectorChemistry

Abstract

Mesenchymal precursors cells have been isolated from perivascular niches from a range of tissues utilizing a perivascular marker. A new mesenchymal precursor cell phenotype is described characterized by the presence of the perivascular marker 3G5, and preferably also alpha smooth muscle actin together with early developmental markers such as STRO-1 and CD146/MUC18. The perivascular mesenchymal precursor cell is shown to induce neovascularization and improvement in cardiac function. Suitable administration of preparations of the mesenchymal precursor cells are useful for treatment of cardiovascular diseases, cerebrovascular diseases and peripheral vascular diseases.

Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.