Patent · US Active

Identification of 5-methyl-C in nucleic acid templates

US9175348B2 · kind B2 · utility

28Cited by

13References

13Claims

0Family size

Assignee

PACIFIC BIOSCIENCES OF CALIFORNIA, INC. · US

Inventors

Jonas Korlach · Camas, US
Chuan He · Chicago, US
Tyson A. Clark · Menlo Park, US
Liang Zhang · Sichuan, CN
Xingyu Lu · Shanghai, CN

Key dates

Filing date	Apr 23, 2013
Grant date	Nov 3, 2015
Priority date	—
Expiry date	Jul 31, 2033

Classification

Technology area (CPC C)Chemistry; Metallurgy
CPC primaryC12Q1/6869
WIPO fieldBiotechnology
WIPO sectorChemistry

Abstract

A method for identifying a 5-MeC in a template nucleic is provided. The method comprises providing a template having 5-MeC, converting the 5-MeC into a further modification selected from 5-caC and 5-FC. The converted template is then sequenced, and a change in sequencing is detected that is indicative of the further modification, allowing for identifying the 5-MeC in the template nucleic acid.

Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.