Granzyme A and granzyme B diagnostics
US9176138B2 · kind B2 · utility
Assignee
Inventors
Key dates
| Filing date | Apr 25, 2014 |
| Grant date | Nov 3, 2015 |
| Priority date | — |
| Expiry date | May 2, 2034 |
Classification
- Technology area (CPC G)Physics
- CPC primaryG01N2800/324
- WIPO fieldMeasurement
- WIPO sectorInstruments
Abstract
A method for identifying a subject being at risk for or having a chronic inflammatory disease, fibrillinopathy, atherosclerosis, or coronary artery disease is provided. The method may include determining the concentration of GrA and/or GrB in a blood or serum sample from said subject; and comparing the concentrations to the corresponding concentration in a control sample, wherein an elevated concentration of GrA and/or GrB may be indicative of a chronic inflammatory disease, fibrillinopathy, atherosclerosis, or coronary artery disease. The method may further include identifying concentrations of fibrinogen, elastin and/or fibrillin.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.