Methods and apparatuses for detection of positional freedom of particles in biological and chemical analyses and applications in immunodiagnostics
US9176152B2 · kind B2 · utility
Assignee
Inventors
Key dates
| Filing date | May 25, 2011 |
| Grant date | Nov 3, 2015 |
| Priority date | — |
| Expiry date | Oct 22, 2031 |
Classification
- Technology area (CPC G)Physics
- CPC primaryG03H2001/221
- WIPO fieldMeasurement
- WIPO sectorInstruments
Abstract
The present invention relates to methods and apparatuses for the detection of positional freedom of particles used in biological, biochemical, physical, biophysical, and chemical analyses. In particular, the present invention relates to methods and apparatuses which can detect and characterize a population of particles/cells based upon their detected mobility. In one embodiment consistent with the invention, detection of certain cells is based on differences detected in populations of cells that bind to a substrate and those that exhibit weaker binding forces. Initially, cells are settled on the substrate, and in the presence of gravitational, natural thermodynamic pressure fluctuations, and other random or applied forces, some of the particles may exhibit translational movement. Particle movement is detected, and measurements are computed, according to the methods and apparatuses of the present invention, to determine the binding of specific analytes.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.