Updating landmarks to improve coregistration as regions of interest are corrected

US9177378B2 · kind B2 · utility

Assignee

• Definiens GmbH · DE

Inventors

• Ralf Schoenmeyer · Gilching, DE
• Mehmet Yigitsoy · Munich, DE
• Nicolas Brieu · Munich, DE

Key dates

• Filing date: Jun 22, 2015
• Grant date: Nov 3, 2015
• Expiry date: Jun 22, 2035

Classification

• Technology area (CPC G): Physics
• CPC primary: G06T2207/30172
• WIPO field: Computer technology
• WIPO sector: Electrical engineering

Abstract

The coregistration of digital images of tissue slices is improved by updating landmarks based on the manual outlining of regions of interest on the images. A first image of a first slice is coarsely coregistered with a second image of a second slice using a first landmark on the first image and a second landmark on the second image. A user manually outlines a first region of interest on the first image. The outline is positioned over a second region of interest on the second image using the second landmark. The user manually moves a contour point of the outline on the second image to form a corrected outline. The second landmark is moved based on how the contour point was manually moved so that the first and second images are more finely coregistered after the second landmark is moved. Each state of corrected contour points and landmarks is saved.