Continuous flow mobility classifier interface with mass spectrometer

US9177774B2 · kind B2 · utility

Assignee

• CALIFORNIA INSTITUTE OF TECHNOLOGY · US

Inventors

• Nicholas Brunelli · Atlanta, US
• Konstantinos P. Giapis · Pasadena, US
• Richard C. Flagan · Pasadena, US
• Jesse L. Beauchamp · La Cañada Flintridge, US
• Evan L. Neidholdt · Pasadena, US

Key dates

• Filing date: Jan 18, 2011
• Grant date: Nov 3, 2015
• Expiry date: May 12, 2031

Classification

• Technology area (CPC G): Physics
• CPC primary: G01N30/7233
• WIPO field: Measurement
• WIPO sector: Instruments

Abstract

A continuous flow mobility classifier provide the ability to perform two-dimensional separation in mass spectrometry. An ionization system is used to ionize a sample. A differential mobility analyzer (DMA) (e.g., a nano-radial DMA) is coupled to the ionization system and to a mass spectrometer. The nano-RDMA is configured to separate the ionized sample by mobility for subsequent mass analysis by the mass spectrometer.