Integrated work-flow for accurate input function estimation

US9179885B2 · kind B2 · utility

Assignee

• KONINIKLIJKE PHILIPS N.V. · NL

Inventors

• Jens-Christoph Georgi · Aachen, DE
• Manoj Narayanan · Mentor, US

Key dates

• Filing date: Dec 14, 2011
• Grant date: Nov 10, 2015
• Expiry date: Jul 4, 2032

Classification

• Technology area (CPC G): Physics
• CPC primary: G01T1/16
• WIPO field: Medical technology
• WIPO sector: Instruments

Abstract

When estimating an arterial input function or a patient under study, cross-calibration factors are generated by comparing nuclear scan data of a radioactive material (e.g., F18) and measuring a sample of the radioactive material in a gamma counter. The derived cross-calibration factors are applied to venous samples collected from the patient during a nuclear scan after infusion with a radioactive tracer, to convert gamma values counted by the gamma counter into concentration values. The concentration values are used to optimize an initial estimated input function, thereby generating an arterialized input function.