System and method for ocular iontophoresis with buffering
US9180292B2 · kind B2 · utility
Assignee
Inventors
Key dates
| Filing date | Dec 28, 2009 |
| Grant date | Nov 10, 2015 |
| Priority date | — |
| Expiry date | Mar 12, 2030 |
Classification
- Technology area (CPC A)Human Necessities
- CPC primaryA61N1/0448
- WIPO fieldMedical technology
- WIPO sectorInstruments
Abstract
Compositions, devices, methods of manufacture, and methods of delivery of a therapeutic substance across a surface of an eyeball via iontophoresis including a therapeutic media reservoir and a buffer system within an iontophoretic chamber. When energized, an electrode provides an electromotive force that transfers a dosage of the therapeutic substance from the iontophoretic chamber across the surface of the eyeball. The buffering system includes a buffer media and at least one buffer element, or agent that regulates pH during iontophoretic transfer of the therapeutic substance. The buffer media includes at least one of a foam, a gel (solid or liquid), a membrane, and a plurality of multiparticulates. The buffer media can be included within the iontophoretic chamber, together with the therapeutic media reservoir, in various arrangements including one or more layers and one or more concentric cylinders.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.