Additive for the crystallization of proteins, use and process
US9180386B2 · kind B2 · utility
0Cited by
0References
9Claims
0Family size
Assignees
Inventors
Key dates
| Filing date | Apr 2, 2010 |
| Grant date | Nov 10, 2015 |
| Priority date | — |
| Expiry date | Mar 7, 2033 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC30B29/58
- WIPO fieldChemical engineering
- WIPO sectorChemistry
Abstract
The present invention relates to the use and to a process involving at least one calix[n]arene derivative substituted by at least one acid functional group on the upper face and at least one aliphatic chain of variable length on the other face, as an additive for crystallization of a polar and/or positively charged molecule. The use and the process of the present invention have the advantage of enabling, facilitating and/or accelerating the crystallization of polar and/or positively charged molecules, especially of membrane proteins that are in solution or soluble, which had previously proved to be very difficult.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.