Hydrogenation of ketones having at least a carbon-carbon double bond in the γ,δ-position
US9181163B2 · kind B2 · utility
Assignee
Inventors
Key dates
| Filing date | Jun 13, 2012 |
| Grant date | Nov 10, 2015 |
| Priority date | — |
| Expiry date | Jun 13, 2032 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC07D311/72
- WIPO fieldOrganic fine chemistry
- WIPO sectorChemistry
Abstract
The present invention relates in a first aspect to a process for hydrogenation of ketones having at least a carbon-carbon double bond in the y,8-position to the keto group by hydrogen in the presence of at least one chiral iridium complex of formula (I), where R1 represents a group of formula (II) or (III) or (IV). It has been shown that this process leads to a strong increase in preferential formation of a single isomer. The process is particularly suitable for the hydrogenation of y,8-unsaturated ketones which can be used as flavors and fragrances or for the preparation of vitamin E and its derivatives or of flavors and fragrances.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.