Indenoquinolone compound, preparation method and use thereof
US9181193B2 · kind B2 · utility
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8Claims
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Assignee
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Key dates
| Filing date | May 17, 2011 |
| Grant date | Nov 10, 2015 |
| Priority date | — |
| Expiry date | May 17, 2031 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC07D413/12
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
An indenoquinolone compounds of Formula (A) is disclosed, wherein the definition of each group is described in the description. These compounds may specifically inhibit topoisomerase I, and they have good activities against many kinds of human tumor cells, such as lung cancer, colon cancer, breast cancer, liver cancer and the like. They can be used in the manufacture of antitumor drugs. The method for preparing the compound of formula (A), and pharmaceutical compositions containing such compounds and the use in the manufacture of antitumor drugs are also disclosed.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.