N-(pyridin-2-yl)sulfonamides and compositions thereof as protein kinase inhibitors

US9181238B2 · kind B2 · utility

Assignee

• Novartis AG · CH

Inventors

• Shifeng Pan · Gilroy, US
• John Tellew · Village of La Jolla, US
• Yongqin Wan · Irvine, US
• Yongping Xie · San Diego, US
• Xing Wang · San Diego, US
• Xia Wang · San Diego, US
• Shenlin Huang · Raritan, US
• Zuosheng Liu · San Diego, US
• Qiong Zhang · Plano, US

Key dates

• Filing date: Feb 4, 2011
• Grant date: Nov 10, 2015
• Expiry date: Jul 15, 2032

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C07D401/14
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

The invention provides a novel class of compounds of Formula (I) (wherein A, Y, R2, R3, R4 and R5 are defined in the summary of the invention), pharmaceutical compositions comprising such compounds and methods of using such compounds to treat or prevent diseases or disorders associated with abnormal or deregulated kinase activity, particularly diseases or disorders that involve abnormal activation of B-Raf.