Solvate form M of trametinib dimethyl sulfoxide and methods of making and using thereof
US9181243B2 · kind B2 · utility
1Cited by
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23Claims
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Key dates
| Filing date | Jun 30, 2014 |
| Grant date | Nov 10, 2015 |
| Priority date | — |
| Expiry date | Jun 30, 2034 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC07B2200/13
- WIPO fieldOrganic fine chemistry
- WIPO sectorChemistry
Abstract
The present invention relates to a crystalline Form M of trametinib dimethyl sulfoxide solvate. Comparing with the prior art, Form M is a more stable crystalline form with better particle size distribution and good flowability and is non-hygroscopic. Therefore, it is more suitable for formulation. The present invention also relates to pharmaceutical compositions thereof, methods of making and using thereof. Trametinib dimethyl sulfoxide solvate has a structure as shown below:
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.