Substituted 2,3-dihydro-1H-benzo[a]pyrano[2,3-c]phenazines as anti-angiogenic and anti-cancer agents

US9181265B2 · kind B2 · utility

Assignees

• UNIVERSITÉ CATHOLIQUE DE LOUVAIN · BE
• UNIVERSITÉ LIBRE DE BRUXELLES · BE

Inventors

• Olivier Feron · Wezembeek-Oppem, BE
• Olivier Riant · Brussels, BE
• Robert Kiss · South San Francisco, US
• Joelle Leclercq · Beaufays, BE
• Gabrielle Chataigne · Lille, FR
• Nicolas Vandelaer · Bossut-Gottechain, BE
• Carole Lamy · Montigny-le-Bretonneux, FR

Key dates

• Filing date: Dec 22, 2011
• Grant date: Nov 10, 2015
• Expiry date: Dec 22, 2031

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C07D497/04
• WIPO field: Organic fine chemistry
• WIPO sector: Chemistry

Abstract

Novel phenazine derivatives of formula (I)are disclosed. In particular, substituted 2,3-dihydro-1H-benzo[a]pyrano[2,3-c]phenazines are disclosed. The compounds can be used as anti-angiogenic and/or anti-tumor agents.