Cationic lipids with various head groups for oligonucleotide delivery
US9181295B2 · kind B2 · utility
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8Claims
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Key dates
| Filing date | Aug 18, 2010 |
| Grant date | Nov 10, 2015 |
| Priority date | — |
| Expiry date | Dec 3, 2030 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC07J43/003
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
The instant invention provides for novel cationic lipids that can be used in combination with other lipid components such as cholesterol and PEG-lipids to form lipid nanoparticles with siRNA, to facilitate the cellular uptake and endosomal escape, and to knockdown target mRNA both in vitro and in vivo.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.