Modulated lysine variant species compositions and methods for producing and using the same

US9181337B2 · kind B2 · utility

Assignee

• Abb Vie Inc. · US

Inventors

• Kartik Subramanian · Northborough, US
• Mayda Perez Thiele · Vega Alta, US
• Xiaobei Zeng · Carolina, US
• Chee Furng Wong · Singapore, SG
• Zehra Kaymakcalan · Westborough, US
• Ying Jing · Wellesley, US
• Christopher Chumsae · North Andover, US

Key dates

• Filing date: Nov 12, 2013
• Grant date: Nov 10, 2015
• Expiry date: Nov 12, 2033

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C07K2317/565
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

The instant invention relates to modulated lysine variant species compositions comprising a protein, e.g., an antibody, or antigen-binding portion thereof, and methods, e.g., cell culture and/or protein purification methods, for producing such modulated lysine variant species compositions. Methods for using such compositions to treat a disorder, e.g., a disorder in which TNFα is detrimental, are also provided.