Patent · US Active

Dual variable region antibody-like binding proteins having cross-over binding region orientation

US9181349B2 · kind B2 · utility

21Cited by

7References

26Claims

0Family size

Assignee

Sanofi · FR

Inventors

Nicolas Baurin · Arpajon, FR
Chirstian Biel · Kelkheim, DE
Carsten Corvey · Frankfurt am Main, DE
Christian Lange · Frankfurt am Main, DE
Danxi Li · Skillman, US
Vincent Mikol · Charenton-le-Pont, FR
Anke Steinmetz · Vitry-sur-Seine, FR
Ercole Rao · Frankfurt am Main, DE

Key dates

Filing date	Mar 14, 2013
Grant date	Nov 10, 2015
Priority date	—
Expiry date	Apr 18, 2033

Classification

Technology area (CPC C)Chemistry; Metallurgy
CPC primaryC07K2318/00
WIPO fieldBiotechnology
WIPO sectorChemistry

Abstract

The invention provides antibody-like binding proteins comprising four polypeptide chains that form four antigen binding sites, wherein each pair of polypeptides forming an antibody-like binding protein possesses dual variable domains having a cross-over orientation. The invention also provides methods for making such antigen-like binding proteins.

Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.