Method for controlling the chaperone activity of peroxiredoxins using irradiation
US9181542B2 · kind B2 · utility
Assignee
Inventors
Key dates
| Filing date | Oct 25, 2011 |
| Grant date | Nov 10, 2015 |
| Priority date | — |
| Expiry date | Oct 25, 2031 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC12Y111/01015
- WIPO fieldBiotechnology
- WIPO sectorChemistry
Abstract
The present invention relates to a method for increasing chaperone activity by irradiating peroxiredoxin (Prx) proteins. More particularly, the present invention may be useful for preparing recombinant proteins imparting resistance against various environmental stresses by increasing the chaperone activity of peroxiredoxin, since it has been observed that irradiated peroxiredoxin has enhanced chaperone activity characteristics, wherein an α-helix structure decreases while a β-sheet structure increases, from analysis results of a protein structure change and chaperone activity after irradiating two types of peroxiredoxins (2-Cys, 3-Cys) which are two active cysteine motifs of peroxiredoxin.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.