Naphthalene-based two-photon fluorescent probes, preparation method and use thereof
US9182350B2 · kind B2 · utility
Assignees
Inventors
Key dates
| Filing date | Mar 5, 2012 |
| Grant date | Nov 10, 2015 |
| Priority date | — |
| Expiry date | Mar 5, 2032 |
Classification
- Technology area (CPC G)Physics
- CPC primaryG01N2201/0697
- WIPO fieldMeasurement
- WIPO sectorInstruments
Abstract
The present invention provides a novel category of naphthalene-based two-photon fluorescent probes having a general formula I, wherein: X is selected from the X1, X2, X3 and X4; The mentioned two-photon fluorescent probes have a low fluorescence background in the non-tumor cells and tissues, and have a strong and specific fluorescent signal in the tumor cells and tissues. These probes have a certain level of water-solubility, while having good membrane permeability. In addition, they have a bigger effective two-photon absorption cross section. The compounds of the present invention also have a lower biotoxicity, phototoxicity and photobleaching. There is sufficient difference between the spectral range thereof and that of a biological sample.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.