Nonlinear optical detection of molecules comprising an unnatural amino acid possessing a hyperpolarizability
US9182406B2 · kind B2 · utility
4Cited by
127References
14Claims
0Family size
Assignee
Inventor
Key dates
| Filing date | Aug 4, 2009 |
| Grant date | Nov 10, 2015 |
| Priority date | — |
| Expiry date | Oct 23, 2031 |
Classification
- Technology area (CPC G)Physics
- CPC primaryG01N2500/04
- WIPO fieldMeasurement
- WIPO sectorInstruments
Abstract
A system for making molecules, and proteins in particular, suitable for detection by a surface-selective nonlinear optical technique. A first use of the invention is for determining a protein's structure in real space and real time. A second use of the invention is to detect a protein or its activity (conformational change). A third use of the invention is for drug screening. A further aspect of the present invention is measuring probe tilt angle orientation in an oriented protein.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.