Comparative analysis of protein conformations by using 2D NOESY NMR spectra
US9182467B2 · kind B2 · utility
15Cited by
4References
34Claims
0Family size
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Key dates
| Filing date | Apr 15, 2008 |
| Grant date | Nov 10, 2015 |
| Priority date | — |
| Expiry date | Aug 24, 2030 |
Classification
- Technology area (CPC G)Physics
- CPC primaryG01R33/5605
- WIPO fieldMeasurement
- WIPO sectorInstruments
Abstract
The present disclosure provides a method for determining the relative conformations of a protein provided in different protein preparations, comprising steps of: (i) obtaining a first 2D NOESY NMR spectrum of a first protein preparation; (ii) obtaining a second 2D NOESY NMR spectrum of a second protein preparation; and (iii); determining whether a protein has a different conformation in the first and second protein preparations by comparing one or more cross-peaks in the first 2D NOESY NMR spectrum with one or more corresponding cross-peaks in the second 2D NOESY NMR spectrum.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.