Optical tissue sectioning using full field optical coherence tomography
US9185357B2 · kind B2 · utility
Assignee
Inventors
Key dates
| Filing date | Sep 19, 2011 |
| Grant date | Nov 10, 2015 |
| Priority date | — |
| Expiry date | Jun 7, 2032 |
Classification
- Technology area (CPC G)Physics
- CPC primaryG02B21/367
- WIPO fieldAudio-visual technology
- WIPO sectorElectrical engineering
Abstract
According to a first aspect, the invention relates to a multimodal optical sectioning microscope (200, 400, 600) for full-field imaging of a volumic and scattering sample comprising: —a full-field OCT system for providing an image of a first section in depth of the sample comprising an illumination sub-system (201, 401, 601) and a full-field imaging interferometer with a detection sub system (208, 408, 608) and an optical conjugation device for optically conjugating the sample and said detection sub system, wherein said optical conjugation device comprises a microscope objective (203, 403, 603), —a supplementary full-field optical sectioning imaging system for providing a fluorescent image of a second section in depth of said sample comprising a structured illumination microscope with an illumination sub system (623), means (421, 422) for generating at the focal plane of said microscope objective of said full-field imaging interferometer a variable spatial pattern illumination and a detection sub system (624), optically conjugated with said focal plane of the microscope objective.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.